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phenobarbital will lessen the extent or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.fluconazole will raise the stage or outcome of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.primidone will lessen the extent or influence of bortezomib